6-Azasteroids: potent dual inhibitors of human type 1 and 2 steroid 5 alpha-reductase

J Med Chem. 1993 Dec 24;36(26):4313-5. doi: 10.1021/jm00078a022.
No abstract available

MeSH terms

  • 5-alpha Reductase Inhibitors*
  • Animals
  • Azasteroids / chemical synthesis*
  • Azasteroids / pharmacology
  • Baculoviridae / genetics
  • Cell Line
  • Dihydrotestosterone / metabolism
  • Humans
  • Isoenzymes / antagonists & inhibitors*
  • Male
  • Moths
  • Orchiectomy
  • Rats
  • Rats, Sprague-Dawley
  • Recombinant Proteins / antagonists & inhibitors
  • Testosterone / metabolism
  • Transfection

Substances

  • 5-alpha Reductase Inhibitors
  • Azasteroids
  • Isoenzymes
  • Recombinant Proteins
  • Dihydrotestosterone
  • Testosterone